man in gym photo by senivpetro on freepik
Photo: Senivpetro, Freepik

Human Growth hormone (HGH) is a synthesized protein hormone. In the human body it is naturally secreted by cells in the pituitary gland in the brain. It controls several complex physiologic processes, including growth and metabolism. As one ages, the level of naturally produced HGH decreases.

What are the signs of HGH deficiency?

  • Anxiety and/or depression
  • Baldness (in men)
  • Decrease in sexual function and interest
  • Decreased muscle mass and strength
  • Difficult to concentration and lack of memory
  • Dry, thin skin
  • Elevated triglyceride levels
  • Fatigue and/or tiredness
  • Heart problems
  • High levels of LDL (the “bad”) cholesterol
  • Lower tolerance to exercise
  • Reduced bone density, making you more susceptible to developing osteoporosis
  • Sensitivity to heat and cold
  • Very low energy levels
  • Weight gain, especially around the waist

What are the benefits of HGH?

  • Direct effects are the result of growth hormone binding its receptor on target cells. Fat cells have growth hormone receptors, and HGH stimulates them to break down triglyceride and supresses their ability to take up and accumulate circulating lipids.
  • Indirect effects are mediated primarily by a insulin-like growth factor-I (IGF-I), a hormone that is secreted from the liver and other tissues in response to growth hormone. A majority of the growth promoting effects of growth hormone is actually due to IGF-I acting on its target cells.

Effects on regeneration

HGH stimulates the liver and other tissues to secrete IGF-I. IGF-I stimulates proliferation of cartilage cells, resulting in bone growth. HGH also exerts direct effect on bone growth in stimulating differentiation of chondrocytes.

IGF-I is also responsible for muscle growth. It stimulates both the differentiation and proliferation of muscle cells. It encourages amino acid uptake and protein synthesis in muscle and other tissues.

Look out for the next article on the metoblic effects of HGH!

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